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1

A convenient synthesis of bisindolyl- and indolylaryl maleic anhydrides

Peter D. Davis, Rino A. Bit, Stephen A. Hurst

Journal:

Tetrahedron Letters

Year:

1990

Language:

english

File:

PDF, 190 KB

english, 1990

2

Discovery of novel biaryl heterocyclic EP1 receptor antagonists

Adrian Hall, Rino A. Bit, Susan H. Brown, Helene M. Chaignot, Iain P. Chessell, Tanya Coleman, Gerard M.P. Giblin, David N. Hurst, Ian R. Kilford, Xiao Q. Lewell, Anton D. Michel, Shiyam Mohamed, Alan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 144 KB

english, 2006

3

The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain

Gerard M.P. Giblin, Rino A. Bit, Susan H. Brown, Hélène M. Chaignot, Anita Chowdhury, Iain P. Chessell, Nicholas M. Clayton, Tanya Coleman, Adrian Hall, Beverley Hammond, David N. Hurst, Anton D. Mich

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 155 KB

english, 2007

4

Novel methylene-linked heterocyclic EP1 receptor antagonists

Adrian Hall, Rino A. Bit, Susan H. Brown, Anita Chowdhury, Gerard M.P. Giblin, David N. Hurst, Ian R. Kilford, Xiao Lewell, Alan Naylor, Tiziana Scoccitti

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 274 KB

english, 2008

5

A Dieckmann/ring expansion approach to tetrahydropyrido- and tetrahydroazepino-[1,2-a]indoles

Rino A. Bit, Peter D. Davis, Christopher H. Hill, Elizabeth Keech, David R. Vesey

Journal:

Year:

1991

Language:

english

File:

PDF, 1.40 MB

english, 1991

6

A convenient synthesis of bisindolylmaleimides

Rino A. Bit, Peter H. Crackett, William Harris, Christopher H. Hill

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 205 KB

english, 1993

7

A mild conversion of maleic anhydrides into maleimides

Peter D. Davis, Rino A. Bit

Journal:

Tetrahedron Letters

Year:

1990

Language:

english

File:

PDF, 218 KB

english, 1990

8

Structure-based design of peptidomimetic antagonists of p56lck SH2 Domain

Christopher J. Hobbs, Rino A. Bit, Andrew D. Cansfield, Bill Harris, Christopher H. Hill, Katherine L. Hilyard, Ian R. Kilford, Eric Kitas, Antonin Kroehn, Peter Lovell, David Pole, Paul Rugman, Brad

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 176 KB

english, 2002

9

Discovery of a Brain-Penetrant S1P3-Sparing Direct Agonist of the S1P1 and S1P5 Receptors Efficacious at Low Oral Dose

Demont, Emmanuel H., Arpino, Sandra, Bit, Rino A., Campbell, Colin A., Deeks, Nigel, Desai, Sapna, Dowell, Simon J., Gaskin, Pam, Gray, James R. J., Harrison, Lee A.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.58 MB

english, 2011

10

Discovery of a Selective S1P1 Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate

Demont, Emmanuel H., Andrews, Benjamin I., Bit, Rino A., Campbell, Colin A., Cooke, Jason W. B., Deeks, Nigel, Desai, Sapna, Dowell, Simon J., Gaskin, Pam, Gray, James R. J.

Journal:

ACS Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.56 MB

english, 2011

11

Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction

Bit, Rino A., Davis, Peter D., Elliott, Lucy H., Harris, William, Hill, Christopher H., Keech, Elizabeth, Kumar, Hari, Lawton, Geoffrey, Maw, Anna, Nixon, John S., Vesey, David R., Wadsworth, Julie, W

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 1.81 MB

english, 1993

12

Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition

Theodoulou, Natalie H., Bamborough, Paul, Bannister, Andrew J., Becher, Isabelle, Bit, Rino A., Che, Ka Hing, Chung, Chun-wa, Dittmann, Antje, Drewes, Gerard, Drewry, David H., Gordon, Laurie, Grandi,

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 6.90 MB

english, 2015

13

Navigating CYP1A Induction and Arylhydrocarbon Receptor Agonism in Drug Discovery. A Case History with S1P 1 Agonists

Taylor, Simon J., Demont, Emmanuel H., Gray, James, Deeks, Nigel, Patel, Aarti, Nguyen, Dung, Taylor, Maxine, Hood, Steve, Watson, Robert J., Bit, Rino A., McClure, Fiona, Ashall, Holly, Witherington,

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.75 MB

english, 2015

14

Discovery of tetrahydro-pyrazolo-pyridine as sphingosine 1-phosphate receptor 3 (S1P 3 )-sparing S1P 1 agonists active at low oral doses

Demont, Emmanuel H, Bailey, James M., Bit, Rino A, Brown, Jack A, Campbell, Colin A, Deeks, Nigel, Dowell, Simon J., Eldred, Colin, Gaskin, Pam, Gray, James R. J., Haynes, Andrea, Hirst, David J., Hol

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 888 KB

english, 2016

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